Education
2004-2008, College of Marine Life Sciences, Ocean University of China, Biological Sciences, Bachelor
2008-2013, College of Marine Life Sciences, Ocean University of China, Marine Biology, Ph.D
Research experiences
2013-2017, Scripps Research Institute (Scripps, FL, USA), Metabolism & Aging, Postdoctoral Research Associate
2017-2020, College of Marine Life Sciences, Ocean University of China, Postdoctoral Research Associate
2020-Present, Ocean University of China, College of Marine Life Sciences, Associate Professor
Main research directions and interests
Molecular genetics and comparative biology of molluscan stem cells
1) Cross-species genetic models to investigate the molecular basis of molluscan stem cells, such as HSCs
2) Molecular and cellular biology of important traits regarding development, growth and evolution
3) Establishment of molluscan research models (Mulinia lateralis etc.), with genome editing and transgenics as core technologies.We have systematically studied the evolution of sex-determining genes in a variety of representative dioecious scallops, analyzed the molecular mechanism of sex differentiation in aquaculture shellfish such as Patinopecten yessoensis and Argopecten irradians, and established genetic sex identification methods for various economic shellfish, as well as techniques to regulate testis development for hermaphroditic scallops.
Representative publications (#equal contribution; *corresponding author)
1. Wang Y#, Zhu X#, Lian S*, Li Y, Hu N, Hu X, Bao Z and Wang S. Functional characterization of Cfap206 for bivalve ciliogenesis by RNAi and CRISPR/Cas9 technologies. Frontiers in Marine Science. 2022, 9: 864037.
2. Hu N, Lian S*, Zhu X, Chen X, Sun F, Zhang L, Wang S, Bao Z, Hu J*. Interferon regulatory factors functioned as activators of the interferon pathway in the scallop Chlamys farreri. Frontiers in Marine Science. 2022, 9: 865707.
3. Chen X#, Hu N#, Lian S*, Li L, Sun F, Zhang L, Wang S, Bao Z, Hu J*. Genome-wide identification and expression profiling of COMMD gene family in four bivalve molluscs. Frontiers in Marine Science. 2022, 9: 884991.
4. Xu K#, Wang Y#, Lian S*, Hu N, Chen X, Dai X, Zhang L, Wang X, JHu J, Hu X, Bao Z. Expansion of C1Q genes in Zhikong scallop and their expression profiling after exposure to the toxic dinoflagellates. Frontiers in Marine Science. 2021, 8: 640425.
5. Zhu X#, Zhang F#, Lian S*, Wang Y, Hu N, Chen X, Dai X, Hu X, Wang S, Bao Z. IAPs Gene Expansion in the Scallop Patinopecten yessoensis and Their Expression Profiles After Exposure to the Toxic Dinoflagellate. Frontiers in Physiology. 2021, 12: 633301.
6. Zhao L#, Lian S#, en Q, Yang Z, Guo Z, Lou J, Kong X, Li M, Bao Z, Hu X*. In vivo and rapid assessment of scallop muscle trait. Aquaculture. 2021, 530.
7. Wang J#, Zhang L#, Lian S#, Qin Z#, Zhu X#, Dai X, Huang Z, Ke C, Zhou Z, Wei J, Liu P, Hu N, Zeng Q, Cui C, Dong B, Dong Y, Kong D, Zhang Z, Liu S, Xia Y, Li Y, Zhao L, Xing Q, Huang X, Hu X, Bao Z, Wang S*. Evolutionary transcriptomics of metazoan biphasic life cycle supports a single intercalation origin of metazoan larvae. Nature Ecology & Evolution. 2020, 4:1-12.
8. Lian S#, Zhao L#, Xun X, Lou J, Li M, Li X, Wang S, Zhang L, Hu X* and Bao Z. Genome-wide identification and characterization of SODs in Zhikong scallop reveals gene expansion and regulation divergence after toxic dinoflagellate exposure. Marine Drugs. 2019, 17: 700.
9. Lian S#, Wang J#, Zhang L, Xing Q, Hu N, Liu S, Dai X, Zhang F, Hu X, Bao Z and Wang S*. Integration of biochemical, cellular, and genetic indicators for understanding the aging process in a bivalve mollusk Chlamys farreri. Marine Biotechnology. 2019, 21: 718-730.
10. Zhao L#, Li Y#, Lou J, Yang Z, Liao H, Fu Q, Guo Z, Lian S*, Hu X and Bao Z. Transcriptomic profiling provides insights into inbreeding depression in Yesso scallop Patinopecten yessoensis. Marine Biotechnology. 2019, 21: 623-633.
11. Li X#, Wang S#, Xun X, Zhang M, Wang S, Li H, Zhao L, Fu Q, Wang H, Li T, Lian S, Xing Q, Li X, Wu W, Zhang L, Hu X* and Bao Z. A carotenoid oxygenase is responsible for muscle coloration in scallop. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2019, 1864: 966-975.
12. Li Y, Wang R, Xun X, Wang J, Bao L, Thimmappa R, Ding J, Jiang J, Zhang L, Li T, Lv J, Mu C, Hu X, Zhang L, Liu J, Li Y, Yao L, Jiao W, Wang Y, Lian S, Zhao Z, Zhan Y, Huang X, Liao H, Wang J, Sun H, Mi X, Xia Y, Xing Q, Lu W, Osbourn A, Zhou Z*, Chang Y*, Bao Z*, and Wang S*. Sea cucumber genome provides insights into saponin biosynthesis and aestivation regulation. Cell Discovery. 2018, 4:29.
13. Liu S#, Chen X#, Lian S*, Dai X, Hu N, Zhang F, Zhang L, Bao Z and Wang S. Genome-wide identification and expression profiling of the Wnt gene family in three bivalve molluscs. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics. 2018, 29: 299-307.
14. Sasaki T#, Lian S#, Khan A, Llop J, Samuelson A, Chen W, Klionsky D and Kishi S*. Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase. Autophagy. 2017, 13: 386-403.
15. Song Y#, Shi Y#, Carland T, Lian S, Sasaki T, Schork N, Head S, Kishi S* and Schimmel P*. p53-Dependent DNA damage response sensitive to editing-defective tRNA synthetase in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 2016, 113: 8460-8465.
16. Sasaki T, Lian S, Qi J, Bayliss P, Carr C, Johnson J, Guha S, Kobler P, Catz S, Gill M, Jia K, Klionsky D and Kishi S*. Aberrant Aautolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency. Plos Genetics. 2014, 10.
