Education
2005-2009, Ocean University of China, Biotechnology & Computer Science and Technology, Double BA Degrees
2011-2017, Auburn University (US), Aquatic Genomics, Ph.D
Research experiences
2017-2020, University of Chicago (US), Postdoctoral Scholar
2021-2023, Ocean University of China, Associate Professor
2023-present, Ocean University of China, Professor
Main research directions and interests
Being engaged in functional genomics research for a long time, responsible for and participated in the research and development of a series of large-scale omics projects. Having rich working experience, especially in the direction of genome assembly strategy with highly repetitive sequences, sex determination mechanism, multi-omics analysis of aquatic adaptive traits and genome structural variations, etc, and having mastered advanced omics technology and theoretical accumulation. Papers have been published as a first or a corresponding author in journals such as Nat Ecol Evol, Nat Cancer, Nat Commun, BMC Biol, Mol Ecol Resour, Cell Discov, etc.
Representative publications (#equal contribution; *corresponding author)
1. Han W#, Liu L#, Wang J#, Wei H#, Li Y#, Zhang L#, Guo Z, Li Y, Liu T, Zeng Q, Xing Q, Shu Y, Wang T, Yang Y, Zhang M, Li R, Yu J, Pu Z, Lv J, Lian S, Hu J, Hu X, Bao Z, Bao L*, Zhang L*, Wang S*. Ancient homomorphy of molluscan sex chromosomes sustained by reversible sex-biased genes and sex determiner translocation. Nature Ecology & Evolution. 2022, 6: 1891-1906. (Cover Story)
2. Bao L, Zhong X, Yang Y, Yang L*. Starfish infers signatures of complex genomic rearrangements across human cancers. Nature Cancer. 2022, 3:1247-1259.
3. Bao L, Tian C, Liu S, Zhang Y, Elaswad A, Yuan Z, Khalil K, Sun F, Yang Y, Zhou T, Li N, Tan S, Zeng Q, Liu Y, Li Y, Li Y, Gao D, Dunham R, Davis K, Waldbieser G, Liu Z*. The Y chromosome sequence of the channel catfish suggests novel sex determination mechanisms in teleost fish. BMC Biology. 2019, 17: 6.
4. Liu Z#*, Liu S#, Yao J#, Bao L#, Zhang J#, Li Y#, Jiang C, Sun L, Wang R, Zhang Y, Zhou T, Zeng Q, Fu Q, Gao S, Li N, Koren S, Jiang Y, Zimin A, Xu P, Phillippy AM, Geng X, Song L, Sun F, Li C, Wang X, Chen A, Jin Y, Yuan Z, Yang Y, Tan S, Peatman E, Lu J, Qin Z, Dunham R, Li Z, Sonstegard T, Feng J, Danzmann R, Schroeder S, Scheffler B, Duke M, Ballard L, Kucuktas H, Kaltenboeck L, Liu H, Armbruster J, Xie Y, Kirby ML, Tian Y, Flanagan M, Mu W, Waldbieser G. The channel catfish genome sequence provides insights into the evolution of scale formation in teleosts. Nature Communications. 2016, 7.
5. He Y#, Chang Y#, Bao L#, Yu M#, Li R#, Niu J, Fan G, Song W, Seim I, Qin Y, Li X, Liu J, Kong X, Peng M, Sun M, Wang M, Qu J, Wang X, Liu X, Wu X, Zhao X, Wang X, Zhang Y, Guo J, Liu Y, Liu K, Wang Y, Zhang H, Liu L, Wang M, Yu H, Wang X, Cheng J, Wang Z, Xu X, Wang J, Yang H, Lee SM, Liu X, Zhang Q*, Qi J*. A chromosome-level genome of black rockfish, Sebastes schlegelii, provides insights into the evolution of live birth. Molecular Ecology Resources. 2019, 19: 1309-1321.
6. Li Y#, Wang R#, Xun X#, Wang J#, Bao L#, Thimmappa R#, Ding J#, Jiang J#, Zhang L, Li T, Lv J, Mu C, Hu X, Zhang L, Liu J, Li Y, Yao L, Jiao W, Wang Y, Lian S, Zhao Z, Zhan Y, Huang X, Liao H, Wang J, Sun H, Mi X, Xia Y, Xing Q, Lu W, Osbourn A, Zhou Z*, Chang Y*, Bao Z*, Wang S*. Sea cucumber genome provides insights into saponin biosynthesis and aestivation regulation. Cell Discovery. 2018, 4: 29.
7. Zeng Q#, Liu J#, Wang C#, Wang H, Zhang L, Hu J, Bao L* and Wang S*. High-quality reannotation of the king scallop genome reveals no ‘gene-rich’ feature and evolution of toxin resistance. Computational and Structural Biotechnology Journal. 2021, 19: 4954-4960.
8. Wang H#, Lv J#, Zeng Q*, Liu Y, Xing Q, Wang S, Hu J, Bao L*. Genetic differentiation and selection signatures in two bay scallop (Argopecten irradians) breeds revealed by whole-genome resequencing analysis. Aquaculture. 2021, 543: 736944.
9. Dai X#, Zhu X#, Bao L#, Chen X, Miao Y, Li Y, Li Y, Lv J, Zhang L, Huang X, Bao Z, Wang S*, Wang J*. Decoding the byssus fabrication by spatiotemporal secretome analysis of scallop foot. Computational and Structural Biotechnology Journal. 2022, 20: 2713-2722.
