Education

1998-2002, Ocean University of China, Marine Biotechnology & Computer Science, Bachelor

2002-2007, Ocean University of China, Genetics, Ph.D

Research experiences

2007-2009, University of Texas at Austin, Integrative Biology, Postdoctoral Associate

2009-2010, University of Texas at Austin, Neurobiology, Postdoctoral Associate

2011-Present, Ocean University of China, Professor

2020-Present, Ocean University of China, Fang Zongxi Center for Marine Evo-Devo, Principal Investigator

Main research directions and interests

Our group is mainly engaged in genetic and genomic research on marine molluscs. Our group particularly focuses on the development of cutting-edge technologies suitable for genomic research in non-model organisms, investigation the evolution of molluscan genomes and developmental mechanisms. Our goal is to understand the origin and evolution of molluscs based on systems biology approaches, with evolutionary implications for whole animal kingdom.

Representative publications (#equal contribution; *corresponding author)

1. Wei J#, Liu P#, Liu F#, Jiang A, Qiao J, Pu Z, Wang B, Jia D, Li Y*, Wang S*, Dong B*. EDomics: a comprehensive and comparative multi-omics database for animal evo-devo. Nucleic Acids Research. 2023, 51: D913-D923.

2. Han W#, Liu L#, Wang J#, Wei H#, Li Y#, Zhang L#, Guo Z, Li Y, Liu T, Zeng Q, Xing Q, Shu Y, Wang T, Yang Y, Zhang M, Li R, Yu J, Pu Z, Lv J, Lian S, Hu J, Hu X, Bao Z, Bao L*, Zhang L*, Wang S*. Ancient homomorphy of molluscan sex chromosomes sustained by reversible sex-biased genes and sex determiner translocation. Nature Ecology & Evolution. 2022, 6: 1891-1906. (Cover Story)

3. Thimmappa R, Wang S#, Zheng M#, Misra RC, Huang AC, Saalbach G, Chang Y, Zhou Z, Hinman V, Bao Z, Osbourn A*. Biosynthesis of saponin defensive compounds in sea cucumbers. Nature Chemical Biology. 2022, 18: 774-781.

4. Sun Z#, Huang S#,*, Zhu P, Tzehau L, Zhao H, Lv J, Zhang R, Zhou L, Niu Q, Wang X, Zhang M, Jing G, Bao Z, Liu J, Wang S*, Xu J*. Species-resolved sequencing of low-biomass or degraded microbiomes using 2bRAD-M. Genome Biology. 2022, 23: 36.

5. Liu F, Li Y*, Yu H, Zhang L, Hu J, Bao Z, Wang S*. MolluscDB: an integrated functional and evolutionary genomics database for the hyper-diverse animal phylum Mollusca. Nucleic Acids Research. 2021, 49: D988-D997.

6. Bao Y#, Zeng Q#, Wang J#, Zhang Z#, Zhang Y#, Wang S#, Wong N#, Yuan W, Huang Y, Zhang W, Liu J, Lv L, Xue Q, Zha S, Peng Z, Yao H, Bao Z, Wang S*, Lin Z*. Genomic insights into the origin and evolution of molluscan red-bloodedness in the blood clam Tegillarca granosa. Molecular Biology and Evolution. 2021, 38: 2351-2365.

7. Wang J#, Zhang L#, Lian S#, Qin Z#, Zhu X#, Dai X, Huang Z, Ke C, Zhou Z, Wei J, Liu P, Hu N, Zeng Q, Dong B, Dong Y, Kong D, Zhang Z, Liu S, Xia Y, Li Y, Zhao L, Xing Q, Huang X, Hu X, Bao Z, Wang S*. Evolutionary transcriptomics of metazoan biphasic life cycle supports a single intercalation origin of metazoan larvae. Nature Ecology & Evolution. 2020, 4: 725-736.

8. Lv J#, Jiao W#, Guo H#, Liu P, Wang R, Zhang L, Zeng Q, Hu X, Bao Z, Wang S*. HD-Marker: a highly multiplexed and flexible approach for targeted genotyping of more than 10,000 genes in a single-tube assay. Genome Research. 2018, 28: 1919-1930.

9. Wang S#, Zhang J#, Jiao W#, Li J#, Xun X#, Sun Y#, Guo X#, Huan P#, Dong B, Zhang L, Hu X, Sun X, Wang J, Zhao C, Wang Y, Wang D, Huang X, Wang R, Lv J, Li Y, Zhang Z, Liu B, Lu W, Hui Y, Liang J, Zhou Z, Hou R, Li X, Liu Y, Li H, Ning X, Lin Y, Zhao L, Xing Q, Dou J, Li Y, Mao J, Guo H, Dou H, Li T, Mu C, Jiang W, Fu Q, Fu X, Miao Y, Liu J, Yu Q, Li R, Liao H, Li X, Kong Y, Jiang Z, Chourrout D*, Li R*, Bao Z*. Scallop genome provides insights into evolution of bilaterian karyotype and development. Nature Ecology & Evolution. 2017, 1: 0120. (Cover Story)

10. Li Y#, Sun X#, Hu X#, Xun X#, Zhang J#, Guo X#, Jiao W, Zhang L, Liu W, Wang J, Li J, Sun Y, Miao Y, Zhang X, Cheng T, Xu G, Fu X, Wang Y, Yu X, Huang X, Lu W, Lv J, Mu C, Wang D, Li X, Xia Y, Li Y, Yang Z, Wang F, Zhang L, Xing Q, Dou H, Ning X, Dou J, Li Y, Kong D, Liu Y, Jiang Z, Li R, Wang S*, Bao Z*. Scallop genome reveals molecular adaptations to semi-sessile life and neurotoxins. Nature Communications. 2017, 8: 1721.

11. Dou J#, Dou H#, Mu C, Zhang L, Zhou Z, Chang Y, Wang J, Li T, Li Y, Hu X, Wang S*, Bao Z*. Whole-genome restriction mapping by “subhaploid”-based RAD sequencing: an efficient and flexible approach for physical mapping and genome scaffolding. Genetics. 2017, 206: 1237-1250.

12. Wang S#,*, Liu P#, Lv J, Li Y, Cheng T, Zhang L, Xia Y, Sun H, Hu X, Bao Z*. Serial sequencing of isolength RAD tags for cost-efficient genome-wide profiling of genetic and epigenetic variations. Nature Protocols. 2016, 11: 2189-2200.

13. Wang S#,*, Meyer E#,*, McKay JK, Matz MV. 2b-RAD: a simple and flexible method for genome-wide genotyping. Nature Methods. 2012, 9: 808-810.

14. Ponomarev I*,#, Wang S#, Zhang L, Harris RA & Mayfield RD*. Gene co-expression networks in human brain identify epigenetic modifications in alcohol dependence. Journal of Neuroscience. 2012, 32: 1884-1897.

15. Wang S*, Zhang L, Meyer E, Matz MV. Construction of a high-resolution genetic linkage map and comparative genome analysis for the reef-building coral Acropora millepora. Genome Biology. 2009, 10: R126